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KMID : 0370219880320060394
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Yakhak Hoeji
1988 Volume.32 No. 6 p.394 ~ p.401
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Development of Lactobacillus casei Resistant to Rifampicin, an Antituberculosis Agent
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Abstract
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Lactobacillus casei was treated with N-methyl-N´-nitro-N-nitrosoguanidine(NTG) to obtain resistant mutants to rifampicin. Freshly grown cells of the strain suspended in tris-maleic acid buffer were exposed to NTG of 50pg/ml for 30min. Five colonies of the NTG-induced mutants showed distinct resistance to rifampicin. They also exhibited identical characteristics with the original Lactobacillus casei when they were tested for growth, titrable acidity and sugar fermentation. It is suggested that they can be utilized as efficieient starter cultures for fermented milk.
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KEYWORD
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